药物化员工物学团队课题组网站：https://www.x-mol.com/groups/li_yizhou

2022.09-至今        bat365，副研究员

2020.09-2022.08  bat365，准聘副教授

2017.09-2020.08  美国伊利诺伊大学芝加哥分校，药物化学，博士后（导师： Prof. Gregory Thatcher）

2012.09-2017.07  中国科学院上海有机化学研究所，药物化学，博士（导师：王任小研究员）

2008.09-2012.07  中国药科大学，药学基地班，学士（导师：陆涛教授）

药物化学，化员工物学

1. 针对表观遗传中Bromodomain相关靶点设计合成选择性抑制剂用于癌症、炎症等疾病的研究。

2. 针对细胞凋亡通路中Bcl-2蛋白家族进行化学小分子抑制剂的药物开发。

3. 开发DNA相容性的化学反应用于DNA编码化合物库的构建。

1.国家自然科学基金青年基金，主持，2022.01-2024.12

1. Shilian Yang^#, Guixian Zhao^#, Yuting Gao, Yang Sun, Xiaohong Fan, Gong Zhang, Yangfeng Li*, Yizhou Li*; In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chemical Science 2022,13, 2604-2613.

2. Xianfu Fang^#, Yiting Wang^#, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li*, Yizhou Li*; Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Organic Letters 2022, 24, 3291-3296.

3. Shuting Zhong^#, Xianfu Fang^#, Yiting Wang, Gong Zhang, Yangfeng Li*, Yizhou Li*; DNA-Compatible Diversification of Indole π-Activated Alcohols via a Direct Dehydrative Coupling Strategy, Organic Letters 2022, 24, 1022-1026.

4. Yuting Gao, Guixian Zhao, Pengyang He, Gong Zhang, Yangfeng Li*, Yizhou Li*; DNA-compatible synthesis of α, β-epoxyketones for DNA-encoded chemical libraries, Bioconjugate Chemistry 2022, 33, 105-110.

5. Daniel Principe^#, Rui Xiong^#, Yangfeng Li, Thao Pham, Suneel Kamath, Oleksii Dubrovskyi, Kiira Ratia, Fei Huang, Jiong Zhao, Zhengnan Shen, Dinesh Thummuri, Daohong Zhou, Patrick Underwood, Jose Trevino, Hidayatullah Munshi, Gregory Thatcher*, Ajay Rana*; XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer, Proceedings of the National Academy of Sciences 2022, 119, e2116764119.

6. Yangfeng Li, Jiong Zhao, Lauren Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra Tonetti, Gregory Thatcher, Rui Xiong*; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib, Journal of Medicinal Chemistry 2020, 63, 7186-7210. (Selected as Cover)

7. Laura Cooper^#, Adam Schafer^#, Yangfeng Li^#, Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert Davey, Gregory Thatcher, Lijun Rong*, Rui Xiong*; Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors, Journal of Medicinal Chemistry 2020, 63, 11085-11099. (Selected as Cover)

8. Yangfeng Li, Biao Yu, Renxiao Wang*; Efficient synthesis of rottlerin and its two subunits, Tetrahedron Letters 2016, 57, 1856-1859.

9. Yangfeng Li, Biao Yu, Jiansong Song*, Renxiao Wang*; Efficient synthesis of baicalin and its analogs, Tetrahedron Letters 2015, 56, 3816-3819.